PHYTOCHEMICAL SCREENING, PROXIMATE ANALYSIS AND ANTI-CANCER ACTIVITY OF ETHANOLIC SEED EXTRACT OF MORINGA OLEIFERA

Authors

  • HAMISU ABDU Department of Polymer Technology, Hussaini Adamu Federal Polytechnic, Kazaure, Jigawa State, Nigeria. Author
  • FAUJAN B. H. AHMAD Natural Product Laboratory, Faculty of Applied Sciences, Universiti Teknologi MARA, Malaysia. Author
  • A. U. ADAMU Department of Polymer Technology, Hussaini Adamu Federal Polytechnic, Kazaure, Jigawa State, Nigeria. Author
  • SAI’DU A.A Department of Science Lab. Technology, Hussaini Adamu Federal Polytechnic, Kazaure, Jigawa State, Nigeria. Author

Keywords:

Proximate analysis, Phytochemical screening, Anti-ulcer activity, Moringa oleifera, cancer cell lines

Abstract

Moringa oleifera is a native tree which has been reported to have medicinal properties. The leaves and the seeds were traditionally reported for the treatment of peltic ulcers and have an anti-cancer properties. The objectives of this study was to carry the phytochemical screening, proximate analysis and anti-cancer activity of the seed ethanolic extracts of Moringa oleifera (Lam). The preliminary phytochemical screening revealed the presence of flavonoids, Saponin, Alkaloids, Steroids and terpenoids and the results of proximate analysis in methanolic Moringa oleifera leaves extract shows relatively low moisture content (9.21%) and low protein content (6.22%), however, it shows high carbohydrate content (49.60%) and high fibre content (23.77%).  The anti-cancer activity of the ethanolic seed extract of Moringa oleifera seed was evaluated against HL-60 Cancer cell line (Human T-promyelocytic leukemia), MCF-7 Cancer cell lines (Human breast cancer), HeLa Cancer cell line (Human cervical carcinoma cancer) and mouse embryonic fibroblast normal cell line (3T3) lines with with IC50 values of 8.51, 8.62, 12.33 and 2.78 µg/ml respectively. These findings suggested that Moringa oleifera seeds possess anti-cancer properties which have the potential to contribute to its ethno-medicinal uses.

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Published

2023-12-31

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How to Cite

PHYTOCHEMICAL SCREENING, PROXIMATE ANALYSIS AND ANTI-CANCER ACTIVITY OF ETHANOLIC SEED EXTRACT OF MORINGA OLEIFERA. (2023). Journal of Health, Metabolism and Nutrition Studies, 2(2). https://berkeleypublications.com/bjhmns/article/view/82

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